ncRNA name | rno-miR-195-5p |
ncRNA Category | miRNA |
Disease name | uveitis |
Species | Rattus norvegicus |
Tissues/Cell_line | eyes |
Methods | Western blot, immunohistochemistry, miRNA PCR array |
Expression pattern | down-regulated |
Functional description | RvD1 dose-dependently increased the expression of sirtuin-1 (SIRT1) within the eye, while it decreased the expression of acetyl-p53 and acetyl-FOXO1. These effects were accompanied by local downregulation of some microRNAs related to the expression and activity of SIRT1. These were miR-195-5p, miR-200a-3p, miR-34a-5p, and miR-145-5p. |
PubMed ID | 26180376 |
Year | 2015 |
Title | Interplay between Intravitreal RvD1 and Local Endogenous Sirtuin-1 in the Protection from Endotoxin-Induced Uveitis in Rats. |
Drug-related ncRNA | YES (Resolvin D1) |
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